… Gene transfer can be used to modify the genome of domestic livestock. The use of gene …
the efficiency of animal agriculture as the demand for production increases. Animals that have …

… recombination event per cell modified can be as low as 1 in … domestic animals. To overcome
the problem associated with obtaining isogenic targeting constructs from domestic animals, …

… cloning permit the introduction of specific genetic modifications into the genome of domestic
animals. Although gene targeting in mouse ES cells has become a routine procedure in …

… genomic segments of various sizes. Chromosomal rearrangements can lead to significant
modifications … eg duplications and deletions) of genomic regions, shaping phenotypic variation …

… undergoes changes or lead to regulatory modification if the regulatory sequences of the …
and domesticated animals. However, the analysis of the genome sequence of domestic pigs …

… to facilitate multiplexed genomic modifications in one shot, the … transgenic animals, including
creating large animal models … on their application to edit the genome of livestock species. …

… editing provide the unprecedented ability to introduce almost any targeted modification
into genomic DNA and have propelled genome editing from being a technical possibility to a …

… genome modification in large animals and facilitates the generation of genetically modified
large animals … embryos between humans and large domestic animals, including pigs and …

… animals … of genome sequencing projects of three domestic animals (cow, dog, and
horse) and poultry in 1993. All these achievements and endeavors culminated in the whole-genome …